'Cancerous cell in the Middle East...': Iranian-born actor Mandana Karimi speaks out on Iran–Israel–US war; explains why she’s unhappy to see protests in India

Actor Mandana Karimi has broken her silence on the Middle East crisis, describing the deep emotional toll it has taken on her and many Iranians.

In an exclusive interview with NDTV, the Iranian-born actor spoke candidly about the decades-long unrest in her homeland and her anguish over the current situation.

“For years, people inside Iran have protested with our bare hands. We have lost people,” Mandana told NDTV. She described the long history of demonstrations and crackdowns, adding, “We have lost mothers, kids, universities, the list just goes on and on.”


Iran has been under the rule of the Islamic Republic since 1979, following the revolution that reshaped the country’s political system. According to Mandana, frustration among sections of the population has built up over decades.

Decades of Protest in Iran: ‘We Have Been Asking the World to Help Us’

During the interview, Mandana reflected on the reaction of some Iranians to recent developments. She referred to protests and violence earlier this year, saying that many people have endured repeated cycles of unrest.

“We have been asking the world, please help us. We have been fighting for over 48 years,” she said, describing the regime as a destabilising force in the Middle East.

"This regime is a cancerous cell in the Middle East," she added.

Mandana also spoke about personal conversations with family and friends in Iran. “When they call me, they say, ‘Can you believe how many are dead?’” she shared, underlining the distress felt by ordinary citizens.

Her remarks highlight the complex and deeply emotional divisions within parts of the Iranian community, both inside the country and abroad.

Mandana Karimi on Protests in India: ‘My Heart Is Broken’

The actor also expressed disappointment over protests taking place in India, which she believes show support for the Iranian regime.

“Abhi mera dil bahut toot gaya hai because jo protest ho raha hai India mein woh regime ke support mein (hai),” she told NDTV. She added that she had recently attended a candlelight gathering in support of the Iranian people but was unable to secure official permission.

Her comments reflect the wider international debate surrounding the current conflict and the varying perspectives within the global Iranian diaspora.

Middle East Conflict Escalation: What Triggered the Crisis?

The latest escalation began after the United States and Israel launched major strikes on Iranian targets on February 28. Iran’s Supreme Leader, Ayatollah Ali Khamenei, was killed in the attacks. He was 86.

Iran responded with missile and air strikes across parts of the region, including Israel and several Gulf countries. The developments have raised fears of a broader regional conflict.

Inputs from agencies