Coronavirus hotspots emerge in Chinese prisons

Hubei, the hard-hit central province where the virus emerged late last year, said Friday that 271 cases were reported by its prisons on Thursday, including 220 that had previously not been known to provincial authorities.

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Another 34 cases were found at Shilifeng prison in eastern Zhejiang province, leading to the ouster of its director and another official.
BEIJING: More than 400 cases of the new coronavirus have been detected in prisons across China, officials said Friday, fuelling concerns about new clusters of the epidemic.

Hubei, the hard-hit central province where the virus emerged late last year, said Friday that 271 cases were reported by its prisons on Thursday, including 220 that had previously not been known to provincial authorities.

Local Communist Party newspaper Hubei Daily reported that 230 of the prison cases came from a single facility, the Wuhan Women's Prison, whose warden has been removed for failing to prevent the outbreak, while the other 41 cases were reported at a facility in Shayang county.


Seven guards and 200 inmates also tested positive for the virus at Rencheng prison in eastern Shandong province, the provincial health commission said at a press conference.

Xie Weijun, head of Shandong's justice department, was sacked over the outbreak along with two other provincial prison administration officials and five officials from the penitentiary, officials said.

Wu Lei, director of Shandong's prison administration, said the new cases showed that "the implementation of our prevention and control measures has not been effective".
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Another 34 cases were found at Shilifeng prison in eastern Zhejiang province, leading to the ouster of its director and another official.

Hubei announced earlier on Friday that a total of 411 new cases of the virus were confirmed in the province on Thursday, but later revised its figure up to 631 to include the prison numbers.

The clusters came as Chinese authorities have pointed to a drop in officially reported new cases this week as evidence that quarantines and other drastic measures to contain the virus are working.

Most of China remains paralysed over fears of contagion, with schools remaining closed and Beijing ordering those returning to the city to self-quarantine for 14 days.
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New cases at two hospitals in the country's capital have also emerged.

Health officials said 36 patients, medical workers and family members have been infected with the virus at Beijing's Fuxing hospital, which has been partially sealed off since January 31.
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An elderly woman receiving kidney treatment at Peking University People's Hospital also tested positive after two infected relatives visited her earlier this month, the hospital said.

People who came into close contact with those infected at both hospitals are being monitored, while 12 women and 10 infants from the obstetrics ward have been ordered to leave Peking University People's Hospital for their own safety, authorities said.

Members of China's Uighur minority living in exile have also warned of the risk of the coronavirus spreading in internment camps, where rights groups say more than one million people have been rounded up by authorities.

The virus spreads through droplets disseminated by sneezing or coughing, highlighting the risks for large groups of confined people, possibly without adequate access to soap and water.

Scientists announce 'breakthrough' atomic map of coronavirus
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US scientists announced Wednesday they had created the first 3D atomic scale map of the part of the novel coronavirus that attaches to and infects human cells, a critical step toward developing vaccines and treatments.



It came as the death toll from the COVID-19 virus jumped past 2,000, almost all of them in mainland China where 74,185 cases of infection have been confirmed since it first emerged in late December.

US scientists announced Wednesday they had created the first 3D atomic scale map of the part of the novel coronavirus that attaches to and infects human cells, a critical step toward developing vacci..
Read More

The team from the University of Texas at Austin and the National Institutes of Health (NIH) first studied the genetic code of the virus made publicly available by Chinese researchers, and used it to develop a stabilized sample of a key part called the spike protein.



They then imaged the spike protein using cutting-edge technology known as cryogenic electron microscopy, publishing their findings in the journal Science.



"The spike is really the antigen that we want to introduce into humans to prime their immune response to make antibodies against this, so that when they then see the actual virus, their immune systems are ready and loaded to attack," UT Austin scientist Jason McLellan, who led the research, told AFP.

The team from the University of Texas at Austin and the National Institutes of Health (NIH) first studied the genetic code of the virus made publicly available by Chinese researchers, and used it to ..
Read More

He added that he and his colleagues had already spent many years studying other members of the coronavirus family including SARS and MERS, which helped them develop the engineering methods required to keep the spike protein stable.



Their engineered spike protein is itself being tested as a potential vaccine by the NIH.

He added that he and his colleagues had already spent many years studying other members of the coronavirus family including SARS and MERS, which helped them develop the engineering methods required t..
Read More

The model can help scientists develop new proteins to bind to different parts of the spike and prevent it from functioning, to treat those already infected. These are known as antivirals.



"This is a beautifully clear structure of one of the most important coronavirus proteins -- a real breakthrough in terms of understanding how this coronavirus finds and enters cells," said virologist Benjamin Neuman at the Texas A&M University-Texarkana, who was not involved in the work.



"The structure shows that although the spike is made of the three identical proteins, one flexes out above the rest, effectively giving the virus a longer reach," he added.

The model can help scientists develop new proteins to bind to different parts of the spike and prevent it from functioning, to treat those already infected. These are known as antivirals."This is a b..
Read More

A useful aspect of the structure for vaccine development is that it maps out the size and location of chains of sugar molecules the virus uses in part to avoid being detected by the human immune system, added Neuman.



Cryogenic electron microscopy uses beams of electrons to examine the atomic structures of biomolecules that are frozen to help preserve them.

A useful aspect of the structure for vaccine development is that it maps out the size and location of chains of sugar molecules the virus uses in part to avoid being detected by the human immune syst..
Read More

The three scientists credited with developing the technology were awarded the 2017 Nobel prize in chemistry.



The team is sending the map of its molecular structure out to collaborators around the world so they can improve it by making it provoke a greater immune response.

The three scientists credited with developing the technology were awarded the 2017 Nobel prize in chemistry.The team is sending the map of its molecular structure out to collaborators around the worl..
Read More

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