BioNTech shot produces 10x more antibodies than Sinovac: Study

There is a substantial gap in the amount of antibodies that mRNA and inactivated vaccines can generate against the virus that causes Covid-19, according to a Hong Kong study, in the latest finding on what may have contributed to the varied outcomes following mass vaccination using different types of shots.

The research, published in The Lancet on Thursday, found that antibody levels among Hong Kong health workers who have been fully vaccinated with BioNTech SE's mRNA shot are about 10 times higher than those observed in the recipients of the inactivated vaccine from Sinovac Biotech Ltd.

While disease-fighting antibodies don't account for the full picture when it comes to measuring the ability to generate immunity and the effectiveness of Covid vaccines, “the difference in concentrations of neutralizing antibodies identified in our study could translate into substantial differences in vaccine effectiveness,” the researchers said.


The finding adds to a growing body of evidence suggesting the superiority of mRNA vaccines in providing potent and comprehensive protection against Sars-CoV-2 and its variants, compared to vaccines developed by more traditional methods such as inactivated shots.

Countries from Israel to the U.S that have relied mostly on mRNA vaccines from Pfizer Inc. and its German partner BioNTech, as well as Moderna Inc., have seen a marked reduction in infections. Bloomberg