US Stock Market top gainers and losers on November 4: Surrozen, Inc sees 220% jump, Tradr 2X Long SRPT Daily ETF plunges by nearly 67%, NASDAQ, Dow Jones, S&P 500 end on lower side; here’s how key indices performed

Wall Street ended the day on the lower side on Tuesday (November 4, 2025) three major U.S. stock indexes slid well into negative territory. The Dow Jones Industrial Average fell 251.44 points, or 0.53%, to 47,085.24, the S&P 500 lost 80.42 points, or 1.17%, to 6,771.55 and the Nasdaq Composite lost 486.09 points, or 2.04%, to 23,348.64. The S&P 500 and the Nasdaq suffered their biggest one-day percentage drop since October 10.

The sharp drop came apparently as big banks warned that equity markets could be headed for a drawdown, reflecting mounting concerns over stretched valuations. All three major U.S. stock indexes slid well into negative territory after the CEOs of Morgan Stanley and Goldman Sachs stoked fears of a potential market bubble, with the S&P 500 having climbed to a series of all-time highs, largely powered by the artificial intelligence boom.

Tech shares weighed particularly heavily on the Nasdaq, with six of the "Magnificent Seven" AI-related momentum stocks losing ground on the day. The Philadelphia SE Semiconductor index dipped 4.0%.


JPMorgan Chase CEO Jamie Dimon warned in October of the heightened risk of a significant stock market correction within the next six months to two years, citing factors including geopolitical tensions. "A lot of these companies' valuations were pretty stretched and their earnings were good, but not great," Carlson added. "And that's a recipe for profit-taking."

The U.S. government shutdown, the result of a congressional impasse, is nearing the record for the longest ever. The resulting dearth of official government data has led to increased scrutiny of private sources such as ADP's National Employment Report expected Wednesday.

Comments from Federal Reserve officials are being parsed for clues as to how the data-dependent central bank will forge its monetary policy in the absence of crucial economic indicators. Local elections for New York's mayor and governors in New Jersey and Virginia will also be closely tracked.

Tech was down the most among the 11 major sectors comprising the S&P 500, falling 2.3%. Financials led the gainers. Palantir Technologies slid 8.0% despite the data analytics company's better-than-expected fourth-quarter revenue forecast.

List of top gainers and losers on NASDAQ

As of November 4, 2025, 4:15 PM ET, trading on the NASDAQ saw dramatic swings, with several small- and mid-cap stocks leading the list of top gainers and decliners.

Among the most advanced issues, Surrozen, Inc. (SRZNW) surged by a staggering +220%, topping the day’s gainers. It was followed by Evoke Pharma, Inc. (EVOK), which jumped +132.244%, marking one of its strongest single-day performances in recent months. Rafael Holdings, Inc. (RFL) also posted a substantial rise of +97.0075%, while Davis Commodities Limited (DTCK) advanced +63.4615%. Rounding out the top five gainers, Apollomics Inc. (APLMW) climbed +63.388%, underscoring a bullish sentiment across select health- and commodity-linked names.

On the other end of the spectrum, several stocks experienced steep losses. Tradr 2X Long SRPT Daily ETF (SRPU) plunged -66.2218%, leading the list of decliners as leveraged ETFs faced heavy volatility. Mint Incorporation Limited Class A Ordinary Shares (MIMI) dropped -59.0278%, followed by Prelude Therapeutics Incorporated (PRLD), which fell -55.7789% amid weakness in the biotech segment. RiverNorth/DoubleLine Strategic Opportunity Fund, Inc. (OPP) declined -47.5%, and Allurion Technologies, Inc. (ALUR) slipped -41.9192%, rounding off a turbulent trading day for investors in growth and speculative plays.