S&P 500, NASDAQ and Dow Jones fall: Wall Street ends negative, check top gainers and losers of November 6; here’s how key indices performed

US stocks ended the day on Thursday (November 6, 2025) in negative territory, due to the resumption of Tuesday's tech selloff as investors contended with mounting economic uncertainty and stretched valuations. The major US equity indexes lost ground as risk appetite was dampened by worries over inflated stock prices, particularly from artificial intelligence-related momentum shares.

According to Reuters, preliminary data showed the S&P 500 lost 75.43 points, or 1.10%, to end at 6,721.21, while the Nasdaq Composite lost 443.03 points, or 1.88%, to 23,056.77. The Dow Jones Industrial Average fell 389.47 points, or 0.82%, to 46,921.53. AI-adjacent shares provided muscle to the rally in recent months that pushed the indexes to a series of record-setting highs, so weakness in the sector was a stark reminder of Wall Street's reliance on tech.

Top gainers and losers on NASDAQ

Here’s the list of top gainers and losers on NASDAQ as of November 6, 2025, 4:16 PM ET

Top Gainers



JGH — Nuveen Global High Income Fund gained +134.7826%, leading the list of top advancers.

BLLN — BillionToOne, Inc. Class A Common Stock climbed +81.5667%, reflecting significant investor optimism.

BIYA — Baiya International Group Inc. Ordinary Shares rose +73.8277%, maintaining a solid upward trajectory.

FRGE — Forge Global Holdings, Inc. advanced +68.683%, continuing its recent growth trend.

OPP — RiverNorth/DoubleLine Strategic Opportunity Fund, Inc. increased +65.5556%, rounding out the day’s top gainers.

Top losers



DHAIW — DIH Holding US, Inc. dropped -78.9116%, marking the steepest decline of the day.

ENGS — Energys Group Limited Ordinary Shares fell -67.5941%, reflecting a sharp sell-off.

DHAI — DIH Holding US, Inc. decreased -58.9615%, adding further pressure to the company’s shares.

MEHA — Functional Brands, Inc. Common Stock slid -52.7273%, extending recent losses.

CELT — Tradr 2X Long CELH Daily ETF declined -51.791%, closing out the list of the day’s most declined issues.